arrowhead läuft - zu recht

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eröffnet am: 14.02.05 11:14 von: brokeboy Anzahl Beiträge: 349
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14.02.05 11:14
2

2590 Postings, 5225 Tage brokeboyarrowhead läuft - zu recht

...tja - da habe ich vorletzte Woche zwar einige skeptische Stimmen gehört ... und mittlerweile ging Arrowhead Research um 30%.
Hier noch einmal ein ganz interessanter Bericht über eine WIRKLICH CHANCENREICHE NANOAKTIE.

Arrowhead (deutsch "Pfeilspitze") Research trägt seinen Namen zu Recht: Ob es um die Neugründung einer Tochtergesellschaft oder die Beteiligung an aussichtsreichen Start-Ups geht - Arrowhead handelt schnell und zielsicher; vorausgesetzt, die jeweilige Technologie überzeugt, es existiert ein Prototyp sowie eine weitgehende Absicherung durch Patente. Laut einer Studie verfügt das Unternehmen mit 180 US- und internationalen Patenten über das weltweit am besten diversifizierte Patentportfolio im Nanotechnologie-Sektor. Zudem unterstützt man verschiedene Forschungsprogramme auf universitärer Ebene finanziell - im Gegenzug erhält Arrowhead die Vermarktungsrechte.

Finanzierung gesichert

Im Vergleich zu den für die einzelnen Projekte errechneten Marktvolumen (siehe Tabelle) ist das Unternehmen mit einer aktuellen Börsenbewertung von 54,8 Millionen Dollar unglaublich günstig zu haben. Bis 2008 muss Arrowhead für seine einzelnen Projekte jedoch rund 28 Millionen Dollar aufwenden, aktuell verfügt man über einen Cash-Bestand von 8,55 Millionen Dollar (Stand 30. September 2004). Eine Kapitalerhöhung dürfte daher unumgänglich sein. Arrowhead könnte aber auch ausstehende Optionsscheine einlösen, was dem Unternehmen rund 21 Millionen Dollar einbringen würde.

Fazit: Unglaublich günstig. Bei Arrowhead schlagen Anleger gleich mehrere Fliegen mit einer Klappe: Sie investieren in etliche aussichtsreiche Nanotechs und zugleich in unterschiedliche Branchen, die durch die Nanotechnologie maßgeblich beeinflusst werden. Die aktuelle Börsenbewertung zeigt nur einen Bruchteil des wahren Potenzials von Arrowhead. Allerdings müssen Anleger aufgrund der erwarteten Kapitalmaßnahmen mit einem volatilen Kurs rechnen.


Arrowhead - Gelungene Diversifikation

Produktvermarktung
durch drei Tochtergesellschaften

Anwendung
Marktpotenzial
(e) in Mio.$

Aonex
Halbleitermaterialien für Photovoltaik-Markt
75-100

Insert
Partikel für Medikamententransport
1.000

Nanotechnica
Nanoskalige Geräte und Sensoren
4.500

 

 
 

Forschungsprogramme
 
 

Nanoelektronik
Speicher- und Logik-Chips aus Kohlenstoff-Nanoröhren
75.000 (2014)

Nanobiologie
Diagnostik, Medikamentenforschung
6.000

Ferroelektrische Nanomaterialien
in Sensoren, Biochips, Düsen, Antennen, Kondensatoren
12.000

Quelle: Unternehmen; eigene Recherchen

Die "Pfeilspitze" der Nanotechnologie

Arrowhead

 

ISIN
US0427971009

Kurs am 25.01.2005
3,15 ?

Empfehlungskurs
3,25 ?

Ziel
6,50 ?

Stopp
2,50 ?

KGV 2005e
?

Chance/Risiko
5/5
 
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323 Postings ausgeblendet.

30.03.19 13:42

2107 Postings, 3888 Tage macosPipeline aktuell

 
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01.04.19 10:06

2107 Postings, 3888 Tage macosSilencing the critics

vom letzten Jahr
By Anthony King26 November 2018
RNA interference therapy has had a long and winding road from discovery to market
https://www.chemistryworld.com/news/...4.article#.XKEBmAklMDk.twitter

Aussage vom Chef:
?The range of conditions in the firing line of RNAi is impressive and diverse...We can go after diseases and undruggable targets that we could never go after before. There are going to be dozens of new drugs.?

Gruss
 

02.04.19 10:33

2107 Postings, 3888 Tage macosFolie vom R&D Day 16.10.2018

 
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02.04.19 17:45

2107 Postings, 3888 Tage macosARO-HIF2a

Results: We demonstrate that to achieve deep HIF2? mRNA knockdown (KD), functionalizing HIF2 RNAi with PK enhancement and tumor targeting ligand (TTL) is required. Optimization of the HIF2 RNAi construct enabled a 10-fold improvement in potency. Evaluation of a loading dose regimen improved overall HIF2? mRNA KD compared to a single administration of equal total dosage. Utilizing this strategy, we demonstrated that silencing of HIF2? mRNA (85% KD) resulted in tumor growth inhibition in the A498 xenograft model. Significant improvement in overall survival was also seen in a patient derived xenograft model. Histology evaluation of tumor samples revealed extensive tumor destruction with clusters of apoptotic cells and necrosis. Follow-up studies suggest that loading doses can be administered four hours apart without loss in potency. This allows dosing to be completed in one day and may be more acceptable in clinical settings. The maximum HIF2? mRNA KD after a single dose of HIF2 RNAi was achieved about 7 days after dosing and sustained for about one week in the xenograft model. This suggests that dosing can likely be less frequent in clinical settings. An exploratory toxicity study in rats predicts a wide safety margin.
Conclusions: We demonstrate that the TRiM? delivery platform can be utilized to deliver a RNAi therapeutic selectively targeting HIF2? for the treatment of ccRCC. This represents a novel therapeutic approach either as a monotherapy or in combination with other therapies in seeking better tolerated and/or more effective treatment for ccRCC.
https://www.abstractsonline.com/pp8/#!/6812/presentation/1356  

03.04.19 14:20

2107 Postings, 3888 Tage macosARO-HIF2

Optimizing the potency and dosing design for ARO-HIF2: An RNAi therapeutic for clear cell renal cell carcinomahttp://ir.arrowheadpharma.com/static-files/...-4478-87e8-32503e991311  

04.04.19 11:37

2107 Postings, 3888 Tage macosmögliche Krankheiten

die wir bis jetzt anvisieren können, und die durch Patente gesichert sind?
https://drive.google.com/file/d/1mt7UFq_5YyBMHA4HYYWbJrl1a8vARyxI/view  

04.04.19 21:44

2107 Postings, 3888 Tage macos7th Alpha-1 Global Patient Congress

This week, we're attending the 7th Alpha-1 Global Patient Congress to join researchers, physicians, and patients in their efforts to raise #Alpha1Awareness. Learn more at http://ow.ly/NaYV30oizMj
https://twitter.com/ArrowheadPharma?lang=de
 
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07.04.19 12:09

2107 Postings, 3888 Tage macossucht noch Jemand einen Job

Arrowhead sucht einen Pharmaceutical Alliance Manager.
https://arrowheadpharma.com/job/pharmaceutical-alliance-manager/

The Position

Arrowhead seeks an Alliance Manager to interface with current and future pharmaceutical partners.  The Alliance Manager will be the primary day-to-day point of contact with existing and new strategic partners, as well as intra-company functions related to the relationships with partners.  This will include timeline and technical progress communications as well as work progress in compliance with governing collaboration documents.  The ideal candidate will be a highly motivated team player ready to contribute to a growing biotech organization.

The position reports to the Vice President, Program Management and will work closely with other senior managers at Arrowhead.

Darüber hinaus, noch 14 offene Stellen?  

08.04.19 09:02

2107 Postings, 3888 Tage macosLaborfläche

wurde auch vergrößert.

aus dem 10-Q 07.02.2019

In January 2019, the Company entered into amendments to its existing lease for its Madison, Wisconsin research facility.  The amendments add anadditional 13,000 square feet of office and laboratory space to the facility.  The increased capacity of this new facility will accommodate increased researchand development personnel and manufacturing capabilities for the Company?s expanding pipeline of current and future drug candidates. See Note 11 foradditional discussion of these amendments

http://ir.arrowheadpharma.com/static-files/...-4c90-8a38-ffed99bcf83d  

09.04.19 11:16

2107 Postings, 3888 Tage macosvon BikeRieder

https://twitter.com/BikeRieder  
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12.04.19 10:35

2107 Postings, 3888 Tage macosPoster Presentation

Reduction of hepatic Z-alpha1 antitrypsin by RNA interference prevents and reverses liver disease including hepatic mitochondrial injury in the PiZmouse model.
http://ir.arrowheadpharma.com/static-files/...-46f1-9901-0c9c4f65f73e  

12.04.19 12:25

2107 Postings, 3888 Tage macosEASL

Arrowhead Preclinical Data Demonstrates RNAi Therapy Prevents and Reverses Alpha-1 Liver Disease at The International Liver Congress?
April 12, 2019 06:00 AM Eastern Daylight Time
https://www.businesswire.com/news/home/20190412005066/en/
Key results include the following:

       Sustained RNAi reduction of Z-AAT substantially reversed the AATD disease phenotype:
       Deeply reduced monomeric Z-AAT protein in the liver
       Reduced polymeric Z-AAT in the liver
       Prevented the dramatic increase in globule size seen in age-matched control PiZ mice
       Improved abnormal endoplasmic reticulum morphology
       Prevented inflammation
       Prevented/reduced expression of fibrosis, redox-regulation, stress, apoptosis and autophagosome-          associated genes
       Resulted in abundance of healthy mitochondria

 

12.04.19 19:07

2107 Postings, 3888 Tage macosJNJ-3989

Arrowhead Presents Clinical Data on JNJ-3989 (ARO-HBV) at The International Liver Congress?
April 12, 2019 12:45 PM Eastern Daylight Time
https://www.businesswire.com/news/home/20190412005337/en/
Key results from this interim analysis include the following:

   JNJ-3989 rapidly reduced hepatitis B surface antigen (HBsAg) in patients that had 24 weeks or more of HBsAg assay results (n=40) to thresholds possibly associated with improved chances of HBsAg seroclearance1 in many patients, after only 3 doses
       100% of patients (40 of 40) achieved ?1.0 Log10 IU/mL HBsAg reduction
       88% of patients (35 of 40) achieved HBsAg <100 IU/mL
       43% of patients (17 of 40) achieved HBsAg <10 IU/mL
       13% of patients (5 of 40) achieved HBsAg <1 IU/mL
 

16.04.19 11:53

2107 Postings, 3888 Tage macosARO-AAT

Arrowhead Pharmaceuticals Receives FDA Clearance to Begin Phase 2/3 Study of ARO-AAT for Treatment of Alpha-1 Liver Disease
April 15, 2019 07:30 AM Eastern Daylight Time
https://www.businesswire.com/news/home/20190415005133/en/

PASADENA, Calif.--(BUSINESS WIRE)--Arrowhead Pharmaceuticals Inc. (NASDAQ: ARWR) today announced that it has received clearance from the U.S. Food and Drug Administration to proceed with an adaptive Phase 2/3 trial with the potential to serve as a pivotal registrational study of ARO-AAT, the company?s second generation subcutaneously administered RNA interference (RNAi) therapeutic being developed as a treatment for a rare genetic liver disease associated with alpha-1 antitrypsin deficiency (AATD).

Arrowhead intends to initiate the adaptive design, Phase 2/3 study of ARO-AAT in patients with AATD associated liver disease at various sites in the U.S. in the second quarter of 2019, followed by various international sites in Europe, pending regulatory submission and review. The proposed primary objectives are to evaluate safety and pharmacodynamic dose response, and to evaluate efficacy, defined as an improvement in a histologic grading scale of AATD associated liver disease, and no worsening of liver fibrosis based on Ishak score on end of study biopsy. The company plans to provide additional study details following its initiation.  

16.04.19 11:54

2107 Postings, 3888 Tage macosPT Raised to $33

Arrowhead Research (ARWR) PT Raised to $33 at Piper Jaffray
April 15, 2019 4:58 PM EDT
https://www.streetinsider.com/Analyst+PT+Change/...fray/15372742.html  

16.04.19 12:17

2107 Postings, 3888 Tage macos#338

von Holden:YMB

Anyone who is looking for a differentiator in the RNAi space can stop here. This is the first company in the history of the world to receive such an approval. Whether or not Mr. Market gets it is irrelevant (It doesn't). EVERY BP will now have to play ball with ARWR for two simple reasons. 1) Superior proven delivery capability, and 2) The first and only FDA approved commercialization path that allows drugs to move through the clinic without interim filings.

This latter point is completely lost on the investment community. Think about it. ARWR can cruise through the clinic without two previously required filings. That reduces time to market with drugs by many months if not years. Time is money. This reduces commercialization costs by tens of millions for every ARWR drug. Tha's tens of millions that immediately flow to the pre-tax line.

ARO-AAT will be commercialized in 2020. This approval increases ARWR's lead on ALNY's ALN-AAT02 drug by a MINIMUM of a year. The lead now stands at at least 2 years. And every ARWR drug will have a least a year or two advantage over the competition. And what's the competition? Broadly looking at the landscape of companies that MIGHT have competitive delivery instruments it's ALNY and DRNA. And that's a BIG MIGHT. On these down market days it is tough to think about why the market isn't taking this announcement more seriously. Everyone is playing defense. But the value-creation engine at ARWR continues and with balance sheet issues off the table this stock is a generational good bet.
https://finance.yahoo.com/quote/ARWR/community?p=ARWR  

17.04.19 13:11

2107 Postings, 3888 Tage macosHBV

Inside Look: Janssen?s HBV Asset Licensed From Arrowhead Could Become Treatment Franchise Cornerstone
https://www.biospace.com/article/...-treatment-franchise-cornerstone/  

23.04.19 12:54

2107 Postings, 3888 Tage macosBürofläche in Pasadena vergrößert

On April 17, 2019, Arrowhead Pharmaceuticals, Inc. (?the Company?) entered into a new lease for its Pasadena, California corporate headquarters.  The 91month office building lease between the Company and 177 Colorado Owner, LLC is for approximately 24,000 square feet of office space located at 177 E.Colorado Blvd, Pasadena, California, and this lease will replace the Company?s current corporate headquarters office lease.  The increased capacity of thisnew office space compared to the Company?s current corporate headquarters will accommodate increased personnel as the Company?s pipeline of drugcandidates expands and moves closer to market.
http://ir.arrowheadpharma.com/static-files/...-4eed-955d-aeadaf223334
 

24.04.19 13:42

2107 Postings, 3888 Tage macosHBV

Arrowhead Begins Triple Combination Cohort in Chronic HBV Patients and Earns $25 Million Milestone Payment from Janssen
April 24, 2019 07:30 AM Eastern Daylight Time
https://www.businesswire.com/news/home/20190424005179/en/
Christopher Anzalone, Ph.D., president and chief executive officer at Arrowhead, said: ?Both Arrowhead and Janssen share the aim to advance transformational medicines that achieve higher rates of functional cure with a finite treatment duration for patients with chronic hepatitis B viral infection. Beginning this new triple combination cohort in our ongoing AROHBV1001 study has the potential to generate valuable data rapidly.?  

25.04.19 09:57

2107 Postings, 3888 Tage macoswebcast and conference call on May 8. 2019

PASADENA, Calif. --(BUSINESS WIRE)--Apr. 24, 2019-- Arrowhead Pharmaceuticals Inc. (NASDAQ: ARWR) today announced that it will host a webcast and conference call on May 8, 2019 , at 4:30 p.m. EDT to discuss its financial results for the fiscal 2019 second quarter ended March 31, 2019 .
http://ir.arrowheadpharma.com/news-releases/...al-2019-second-quarter  

02.05.19 13:43

2107 Postings, 3888 Tage macosMay 2019 Conferences

Arrowhead Pharmaceuticals to Present at Upcoming May 2019 Conferences
May 02, 2019 07:30 AM Eastern Daylight Time
https://www.businesswire.com/news/home/20190502005181/en/

Bank of America Merrill Lynch 2019 Health Care Conference ? Las Vegas, May 14-16, 2019

May 15, 8:40 a.m. PDT ? Christopher Anzalone, Ph.D., Arrowhead?s president and chief executive officer, will deliver a corporate presentation

Vascular Discovery: From Genes to Medicine 2019 Scientific Sessions (ATVB|PVD) ? Boston, May 14-16, 2019

May 15, 11:00 a.m. EDT ? So Wong, Ph.D., Arrowhead?s director of biology, will deliver a poster presentation titled, ?Reduction in Angiopoietin-Like Protein 3 via RNA Interference Improves Dyslipidemias and Hepatic Steatosis?

2019 National Lipid Association Scientific Sessions ? Aventura, FL, May 16-19, 2019

May 18, 11:25 a.m. EDT ? So Wong, Ph.D., Arrowhead?s director of biology, will deliver a poster presentation titled, ?Personalized Medicine for Dyslipidemias by RNA Interference-Mediated Reductions in Apolipoprotein C3 or Angiopoietin-Like Protein 3?

20th Annual B. Riley FBR Institutional Investor Conference ? Beverly Hills, May 22-23, 2019

May 23, 8:30 a.m. PDT ? Christopher Anzalone, Ph.D., Arrowhead?s president and chief executive officer, will participate in a fireside chat presentation with Mayank Mamtani, B. Riley FBR research analyst  

09.05.19 12:10

2107 Postings, 3888 Tage macossehr gute Quartalskonferenz

very bullisch :-)))

Edited Transcript of ARWR earnings conference call or presentation 8-May-19 8:30pm GMT
Thomson Reuters StreetEvents?May 9, 2019
https://finance.yahoo.com/news/...-earnings-conference-075110997.html
 

15.05.19 19:23

2107 Postings, 3888 Tage macosARO-ANG3

noch zu 100% im Besitz von ARWR hat Blockbusterpotential? Angriff auf den Statinemarkt von 15 Milliarden Dollar?
Und NASH?


So Wong, Ph.D., Arrowhead?s director of biology, will deliver a poster presentation titled, ?Reduction in Angiopoietin-Like Protein 3 via RNA Interference Improves Dyslipidemias and Hepatic Steatosis?
http://ir.arrowheadpharma.com/static-files/...-44a8-82d3-4424e71482ed
 

18.05.19 13:26

2107 Postings, 3888 Tage macoszu ARO-ANG3 und ARO-APOC3 CC vom 8.5.2019

These are both attractive targets that could address a number of high-value, unmet medical needs, and we are the first to use RNAi against them in humans. They each provide a degree of optionality with respect to which patient populations and indications to study and pursue. For each target, there may be opportunities to treat well-defined orphan diseases such as familial chylomicronemia syndrome and homozygous familial hypercholesterolemia as well as higher prevalence diseases such as NASH or even primary and secondary prevention of cardiovascular disease. We will follow where the data lead us, and dependent on patient populations we choose to focus on, we could have a rapid path to pivotal studies. I expect that we will address clear orphan indications immediately, and I think it is even possible that we could be in pivotal studies for both ARO-APOC3 and ARO-ANG3 next year. We could then begin longer-term studies for larger indications concurrently given us a stage market approach where we move toward orphan markets quickly while we wait for studies of larger indications to mature and eventually go-to-market there as well. Our intention is to discuss our plans for the programs in more detail and describe the potential opportunities and development paths later this year.
Importantly, we believe these targets are well suited for RNAi therapy, and we are the first company to use this modality against them in the clinic. We believe that we can build maximum value for our shareholders by focusing on being pioneers rather than followers, and ARO-APOC3 and ANG3 are good examples of this. More broadly, we intend to be first in our target markets where possible. If instances arise where there is an incumbent, we expect to enter a market only if we believe we have clear technological superiority.
https://finance.yahoo.com/news/...-earnings-conference-075110997.html  

18.05.19 13:29

2107 Postings, 3888 Tage macosNational Lipid Association Scientific Sessions

May 18, 2019 11:25 AM EDT
                    §
2019 National Lipid Association Scientific Sessions


So Wong, Ph.D., Arrowhead?s director of biology, will deliver a poster presentation titled, ?Personalized Medicine for Dyslipidemias by RNA Interference-Mediated Reductions in Apolipoprotein C3 or Angiopoietin-Like Protein 3?
http://ir.arrowheadpharma.com/events-and-presentations

 

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